Glutathione Research Compound

Glutathione is a tripeptide of glutamate, cysteine and glycine, and it is a genuine peptide — but an atypical one. The bond between glutamate and cysteine is formed at the glutamate side-chain (γ) carboxyl rather than the α-carboxyl used in every ribosomally synthesised peptide. That is why it is written γ-Glu-Cys-Gly and why the usual one-letter shorthand is imprecise for it.

The reduced form, GSH, carries a free cysteine thiol and has the formula C10H17N3O6S with an average mass of approximately 307.33 g/mol (CAS 70-18-8). Two GSH molecules can join through that thiol to form the disulfide GSSG, C20H32N6O12S2, approximately 612.6 g/mol — a different compound with a different mass.

Because that conversion is a real and easy chemical event, the specific form present in any batch is a matter for the analytical report issued for that batch rather than an assumption. Vial Drop Labs does not restate a form that the batch documentation does not establish.

HPLC reports the area-percent purity of the principal component. For a thiol-containing compound, chromatography is also the practical means of detecting the disulfide species, because the two forms differ in retention as well as in mass.

The two forms are also distinguishable by mass — approximately 307 g/mol for the reduced tripeptide against approximately 613 g/mol for the disulfide dimer — although current Vial Drop Labs reports characterise material chromatographically rather than by mass spectrometry.

A Certificate of Analysis links a submitted sample to the analytical work performed on it. Current Vial Drop Labs reports are produced by validated HPLC-DAD methodology and answer two separate questions — what the material is, and how much of it is present.

Vial Drop Labs publishes independent analytical reports for tested research materials, with available reports accessible through the Research Documentation portal against the research material and the sample identified on each report. Each analytical report applies only to the sample submitted for analysis and should not be interpreted as testing of every vial or production unit.

Not every report is publicly listed. Where no report has been published for a material, the portal shows none rather than substituting another material's, strength's or batch's results. Documentation is never averaged, combined, or extrapolated between lots.

Current reports are issued by an independent third-party analytical laboratory using validated HPLC-DAD methodology. They report chromatographic purity as area %, content per vial against label claim, and identity as conforming by retention-time and UV/DAD comparison against a reference standard. Current reports do not include mass-spectrometry results.

Vial Drop Labs makes no representation that material is pharmaceutical grade, clinical grade, sterile, safe, or approved by any regulatory authority. Published documentation states exactly what was tested, by which method, and on which date — nothing further should be inferred from it.

Material is supplied lyophilised in a sealed glass vial. Store sealed at -20 °C, protect from light and moisture, and allow a cold vial to equilibrate to ambient temperature before opening.

Thiol-containing compounds are oxidation-sensitive; minimising exposure of opened material to air is normal laboratory practice for this class of chemical. Handle using standard laboratory protective equipment and institutional handling procedures.

This material is supplied strictly as a laboratory research chemical. It is not a drug, supplement, cosmetic, food or medical device, and it is not manufactured, labelled or sold for human or animal use of any kind.

Vial Drop Labs does not provide, and cannot provide, dosing, administration, preparation-for-use, therapeutic or clinical guidance. Published information is limited to chemical identity, laboratory handling and analytical documentation.