Research Compound Reference

Epitalon Research

Epitalon, also referred to in scientific literature as Epithalon or Epithalone, is a short tetrapeptide composed of four amino acids: alanine, glutamic acid, aspartic acid, and glycine (Ala-Glu-Asp-Gly; AEDG). This reference describes areas of published scientific investigation only.

For research use only. Not for human consumption.

Chemical identity reference

Name
Epitalon
Alternative names
Epithalon, Epithalone
Sequence
Ala-Glu-Asp-Gly
Abbreviation
AEDG
Peptide length
4 amino acids
Classification
Tetrapeptide
Research category
Cellular and aging-related research
Molecular formula
C14H22N4O9
Molecular weight
390.35 g/mol
CAS number
307297-39-8
Vial Drop research format
Epitalon 10 mg, lyophilised

Introduction

The peptide was developed from research involving Epithalamin, a pineal-derived peptide preparation, and has subsequently been investigated in cellular, animal, and other experimental models.

Published research involving Epitalon has explored areas including cellular aging, telomere biology, telomerase activity, pineal-associated biological processes, and other mechanisms relevant to aging research.

These areas represent experimental research topics and should not be interpreted as evidence of clinical effectiveness or suitability for human use.

Areas of Epitalon Research

Telomere and telomerase research — cell-culture studies have investigated whether Epitalon can influence telomerase activity and telomere length in human somatic cell models. These findings are experimental and should not be extrapolated into claims regarding human longevity or clinical outcomes.

Cellular aging research — Epitalon has been studied in cellular models examining replicative aging, cellular proliferation, and related biological processes.

Animal aging models — animal studies have investigated Epitalon in experimental models involving aging and lifespan-related endpoints. Results from animal models do not establish equivalent effects in humans.

Pineal and neuroendocrine research — research has also examined Epitalon in relation to pineal-associated biological pathways and neuroendocrine processes.

Understanding the evidence

Epitalon has been investigated for several decades, but the published evidence should be interpreted carefully.

Much of the historical research originates from a relatively concentrated group of investigators, and findings across cellular and animal models do not establish clinical effectiveness in humans.

Vial Drop Labs presents this information to describe areas of published scientific investigation — not to make therapeutic, medical, longevity, or human-performance claims.

Research limitations

Published work on this tetrapeptide carries the ordinary limits of experimental research, and those limits should be read alongside every finding described above.

  • Findings from cell culture cannot automatically be extrapolated to intact organisms.
  • Findings from animal studies do not establish human outcomes.
  • Published research does not establish that Epitalon prevents, treats, or cures disease.
  • Research involving telomerase or telomeres should not be presented as evidence that Epitalon extends human lifespan.
  • Additional independent research is needed to characterise its biological activity and mechanisms.

How Vial Drop publishes analytical documentation

Vial Drop Labs publishes independent analytical reports for tested research materials, with available reports accessible through the Research Documentation portal against the research material and the sample identified on each report. Each analytical report applies only to the sample submitted for analysis and should not be interpreted as testing of every vial or production unit.

Not every report is publicly listed. Where no report has been published for a material, the portal shows none rather than substituting another material's, strength's or batch's results. Documentation is never averaged, combined, or extrapolated between lots.

Current reports are issued by an independent third-party analytical laboratory using validated HPLC-DAD methodology. They report chromatographic purity as area %, content per vial against label claim, and identity as conforming by retention-time and UV/DAD comparison against a reference standard. Current reports do not include mass-spectrometry results.

Vial Drop Labs makes no representation that material is pharmaceutical grade, clinical grade, sterile, safe, or approved by any regulatory authority. Published documentation states exactly what was tested, by which method, and on which date — nothing further should be inferred from it.

Laboratory storage and handling

Material is supplied lyophilised in a sealed glass vial. General laboratory practice for lyophilised peptides applies: store sealed at -20 °C for long-term storage, protect from light, and minimise exposure to atmospheric moisture.

Allow a cold sealed vial to equilibrate to ambient temperature before opening so that atmospheric moisture does not condense onto the dry cake. Lyophilised peptide material is hygroscopic, and repeated warm/cold cycling of an opened vial is the most common cause of avoidable degradation in a laboratory setting.

Handle as an uncharacterised laboratory chemical using standard laboratory protective equipment and institutional handling procedures.

Research use only

This material is supplied strictly as a laboratory research chemical. It is not a drug, supplement, cosmetic, food or medical device, and it is not manufactured, labelled or sold for human or animal use of any kind.

Vial Drop Labs does not provide, and cannot provide, dosing, administration, preparation-for-use, therapeutic or clinical guidance. Published information is limited to chemical identity, laboratory handling and analytical documentation.

References

  1. 1.Khavinson VK, Bondarev IE, Butyugov AA. Epithalon peptide induces telomerase activity and telomere elongation in human somatic cells. Bulletin of Experimental Biology and Medicine. 2003;135(6):590–592.PMID: 12937682DOI: 10.1023/A:1025493705728
  2. 2.Khavinson VK, Bondarev IE, Butyugov AA, Smirnova TD. Peptide promotes overcoming of the division limit in human somatic cell. Bulletin of Experimental Biology and Medicine. 2004;137(5):503–506.PMID: 15455129DOI: 10.1023/B:BEBM.0000038164.49947.8C
  3. 3.Anisimov VN, Khavinson VK, Popovich IG, et al. Effect of Epitalon on biomarkers of aging, life span and spontaneous tumor incidence in female Swiss-derived SHR mice. Biogerontology. 2003;4(4):193–202.PMID: 14501183DOI: 10.1023/A:1025114230714
  4. 4.Araj SK, Brzezik J, Mądra-Gackowska K, Szeleszczuk Ł. Overview of Epitalon — Highly Bioactive Pineal Tetrapeptide with Promising Properties. International Journal of Molecular Sciences. 2025;26(6):2691.PMID: 40141333DOI: 10.3390/ijms26062691

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FOR RESEARCH USE ONLY. NOT FOR HUMAN CONSUMPTION.