Research Compound Reference
Melanotan II Research
Melanotan II (MT-II) is a synthetic cyclic peptide developed as an analog of alpha-melanocyte-stimulating hormone (α-MSH), an endogenous peptide involved in melanocortin receptor signaling. This reference describes areas of published scientific investigation only.
For research use only. Not for human consumption.
Chemical identity reference
- Name
- Melanotan II
- Abbreviation
- MT-II
- Classification
- Synthetic cyclic melanocortin peptide analog
- Research category
- Melanocortin receptor research
- Relationship
- Synthetic analog of α-melanocyte-stimulating hormone (α-MSH)
- Reference sequence
- Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH2
- Molecular formula
- C50H69N15O9
- Molecular weight
- 1,024.18 g/mol
- CAS number
- 121062-08-6
- Vial Drop research format
- Melanotan II (MT2) 10 mg, lyophilised
Introduction
MT-II has been used experimentally to investigate melanocortin receptor systems and related biological pathways.
Published research involving Melanotan II includes investigation of melanocortin receptor activity, pigmentation-related biology, feeding and energy-balance pathways, and other physiological processes influenced by melanocortin signaling.
These areas represent experimental research topics and should not be interpreted as evidence of clinical effectiveness or suitability for human use.
Areas of Melanotan II Research
Melanocortin receptor research — Melanotan II has been used as an experimental melanocortin receptor agonist in research examining signaling through the melanocortin receptor family. Melanocortin receptors participate in multiple biological pathways, and activity observed in experimental models does not establish a clinical application.
Pigmentation-related research — because melanocortin signaling participates in melanogenesis, MT-II has been investigated in experimental models involving pigmentation biology and melanocyte-associated pathways. This is described here only as an area of research.
Energy-balance and feeding research — experimental studies have used melanocortin agonists including MT-II to investigate central pathways involved in feeding behaviour and energy homeostasis. These studies are mechanistic research and must not be translated into weight-loss, appetite-suppression, obesity-treatment, or human-performance claims.
Other melanocortin pathways — MT-II has also been used experimentally to investigate other physiological pathways influenced by melanocortin receptor signaling.
Understanding the evidence
Melanotan II is primarily useful in the scientific literature as an experimental tool for investigating melanocortin receptor signaling and related biological pathways.
Findings from receptor studies, cell models, animal experiments, or other experimental systems should not automatically be extrapolated to clinical outcomes.
Vial Drop Labs presents this information to describe areas of published scientific investigation — not to make therapeutic, cosmetic, medical, weight-management, or human-performance claims.
Research limitations
The melanocortin literature is mechanistic, and each of the following limits applies to the research areas described above.
- Receptor activity does not establish clinical effectiveness.
- Findings from animal models cannot automatically be extrapolated to humans.
- Experimental pigmentation findings should not be presented as cosmetic recommendations.
- Feeding or energy-balance research should not be presented as evidence of a weight-loss treatment.
- Published experimental research does not establish that MT-II prevents, treats, or cures disease.
- Additional research is required to characterise melanocortin signaling across different experimental systems.
How Vial Drop publishes analytical documentation
Vial Drop Labs publishes independent analytical reports for tested research materials, with available reports accessible through the Research Documentation portal against the research material and the sample identified on each report. Each analytical report applies only to the sample submitted for analysis and should not be interpreted as testing of every vial or production unit.
Not every report is publicly listed. Where no report has been published for a material, the portal shows none rather than substituting another material's, strength's or batch's results. Documentation is never averaged, combined, or extrapolated between lots.
Current reports are issued by an independent third-party analytical laboratory using validated HPLC-DAD methodology. They report chromatographic purity as area %, content per vial against label claim, and identity as conforming by retention-time and UV/DAD comparison against a reference standard. Current reports do not include mass-spectrometry results.
Vial Drop Labs makes no representation that material is pharmaceutical grade, clinical grade, sterile, safe, or approved by any regulatory authority. Published documentation states exactly what was tested, by which method, and on which date — nothing further should be inferred from it.
Laboratory storage and handling
Material is supplied lyophilised in a sealed glass vial. General laboratory practice for lyophilised peptides applies: store sealed at -20 °C for long-term storage, protect from light, and minimise exposure to atmospheric moisture.
Allow a cold sealed vial to equilibrate to ambient temperature before opening so that atmospheric moisture does not condense onto the dry cake. Lyophilised peptide material is hygroscopic, and repeated warm/cold cycling of an opened vial is the most common cause of avoidable degradation in a laboratory setting.
Handle as an uncharacterised laboratory chemical using standard laboratory protective equipment and institutional handling procedures.
Research use only
This material is supplied strictly as a laboratory research chemical. It is not a drug, supplement, cosmetic, food or medical device, and it is not manufactured, labelled or sold for human or animal use of any kind.
Vial Drop Labs does not provide, and cannot provide, dosing, administration, preparation-for-use, therapeutic or clinical guidance. Published information is limited to chemical identity, laboratory handling and analytical documentation.
References
- 1.Al-Obeidi F, Hadley ME, Pettitt BM, Hruby VJ. Design of a new class of superpotent cyclic α-melanotropins based on quenched dynamic simulations. Journal of the American Chemical Society. 1989;111(9):3413–3416.DOI: 10.1021/ja00191a044
- 2.Hruby VJ, Lu D, Sharma SD, et al. Cyclic lactam α-melanotropin analogues of Ac-Nle4-cyclo[Asp5,D-Phe7,Lys10]α-melanocyte-stimulating hormone-(4-10)-NH2 with bulky aromatic amino acids at position 7 show high antagonist potency and selectivity at specific melanocortin receptors. Journal of Medicinal Chemistry. 1995;38(18):3454–3461.PMID: 7658432DOI: 10.1021/jm00018a005
- 3.Dorr RT, Lines R, Levine N, Brooks C, Xiang L, Hruby VJ. Evaluation of melanotan-II, a superpotent cyclic melanotropic peptide in a pilot phase-I clinical study. Life Sciences. 1996;58(20):1777–1784.PMID: 8637402DOI: 10.1016/0024-3205(96)00160-9
- 4.Fan W, Boston BA, Kesterson RA, Hruby VJ, Cone RD. Role of melanocortinergic neurons in feeding and the agouti obesity syndrome. Nature. 1997;385(6612):165–168.PMID: 8990120DOI: 10.1038/385165a0
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